Carla Perrone Capano

Professor of Physiology
Vice-director of the CIRN

Name Carla
Surname Perrone Capano
Institution University of Naples – Federico II
Address Institute of Genetics and Biophysics, "Adriano Buzzati Traverso", CNR, 80131 Naples, Italy
Carla Perrone Capano


  • Synthesis of rat brain DNA during acquisition of an appetitive task.

    Publication Date: 01/09/1986 on Pharmacology, biochemistry, and behavior
    by Giuditta A, Perrone Capano C, D'Onofrio G, Toniatti C, Menna T, Hyden H

    We have examined the incorporation of [3H-methyl]thymidine into DNA extracted from several brain regions of rats learning a reverse handedness task, of control rats allowed to use their preferred paw, and of control rats left in their home cages. In learning animals, decrements in percent incorporation were observed in the visual cortex, remaining brain, hippocampus and entorhinal cortex. In the latter two regions less marked decreases were present in the active control group. No variation occurred in the sensory-motor cortex. In learning rats the specific radioactivity of neuronal DNA was markedly decreased in the hippocampus and remaining brain. In the former region, a less marked decrease was present in active control rats. In subcellular fractionation studies it was observed that decreases in DNA specific radioactivity prevailed in the mitochondrial fraction isolated from the hippocampus and visual cortex of learning rats. Brain radioactive DNA was widely distributed among fractions differing in their degree of repetitiveness. Its pattern of distribution did not coincide with that of bulk DNA and differed significantly among behavioural groups. The results suggest a non random origin of newly-synthesized brain DNA and its involvement in learning.

  • Brain protein and DNA synthesis during seizures.

    Publication Date: 01/01/1983 on Advances in neurology
    by Giuditta A, Metafora S, Popoli M, Perrone-Capano C
  • DNA turnover in rat cerebral cortex.

    Publication Date: 01/01/1982 on Journal of neurochemistry
    by Perrone-Capano C, D'Onofrio G, Giuditta A

    After the intracranial injection of [methyl-3H]thymidine the specific activity of rat cortical DNA increases rapidly, reaching a maximum at about 5 h. More than half of the radioactive DNA disappears from the tissue in the following few hours. During the same period of time the concentration of radioactive DNA in liver remains essentially constant. Minor variations occur in both organs after 41 h. An apparent rapid turnover of DNA is also present in a fraction of purified neuronal perikarya prepared from the cerebral cortex.