Graziella Mangone

Genetics Specialist

Name Graziella
Surname Mangone
Institution Institut du Cerveau et de la Moelle Epinière – Université Pierre et Marie Curie (Paris)
Address Centre d’Investigation Clinique Bâtiment ICM – 1ère étage – Aile A Hôpital Pitié-Salpêtrière 47 – 83 Boulevard de Hôpital 75013 Paris – France
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Graziella Mangone


  • Leiomyosarcoma of the submandibular gland. Report of a case and review of the literature.

    Publication Date: 01/09/2005 on International journal of oral and maxillofacial surgery
    by Bucci T, Longo F, Mangone GM, Errico ME, Califano L
    DOI: 10.1016/j.ijom.2004.10.027

    This report describes the first case of primary leiomyosarcoma of the submandibular salivary glands and emphasizes the role of immunohistochemical study for a correct diagnosis of this tumour. In line with results of international literature, we associated surgery with radiotherapy and 2 years postoperatively there was no sign of recurrence.

  • Surgical approach to the stylohyoid process in Eagle's syndrome.

    Publication Date: 01/05/2005 on Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons
    by Buono U, Mangone GM, Michelotti A, Longo F, Califano L
    DOI: 10.1016/j.joms.2004.10.013
  • Midline (dermoid) cysts of the floor of the mouth: report of 16 cases and review of surgical techniques.

    Publication Date: 01/11/2003 on Plastic and reconstructive surgery
    by Longo F, Maremonti P, Mangone GM, De Maria G, Califano L
    DOI: 10.1097/01.PRS.0000086735.56187.22

    A retrospective review of 16 cases of midline (dermoid) cysts of the floor of the mouth is presented, evaluating the different surgical approaches. Sixteen cases of patients with a diagnosis of midline cyst of the floor of the mouth, treated at the Maxillofacial Surgery Department of the School of Medicine and Surgery of the "Federico II" University of Naples (Naples, Italy), were observed over a 10-year period, between 1988 and 1998; age, sex, localization, diagnostic technique, and type of treatment were evaluated. Male patients were more frequently affected, with a male-to-female ratio of 3:1 (12:4 cases). Patients ranged in age from 5 to 51 years (average age, 27.8 years). The preoperative assessment was made using ultrasonography in all cases but one, computed tomography in eight cases, and magnetic resonance imaging in three cases. Regarding surgical techniques used, a transcutaneous approach was adopted for median geniohyoid cysts, an extended median glossotomy technique was used for very large median genioglossal cysts, a median glossotomy technique was used for median genioglossal cysts, and a midline incision of the oral mucosa along the lingual frenulum was used for sublingual cysts. During the postoperative course, there were no complications except for modest edema in three cases. Follow-up ranged between 24 months and 12 years; no relapses or malignant changes were observed. In the authors' experience, the intraoral approach was also effective for the treatment of large lesions and led to very good cosmetic and functional results, whereas the extraoral incision was necessary only when the cysts were under the geniohyoid muscle.

  • Cervical ganglioneuroma: report of a case.

    Publication Date: 01/01/2001 on Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery
    by Califano L, Zupi A, Mangone GM, Long F
    DOI: 10.1067/mhn.2001.111370
  • Intraosseous mucoepidermoid carcinoma. Report of a long-term evolution case.

    Publication Date: 01/01/2001 on Oral oncology
    by Maremonti P, Califano L, Mangone GM, Zupi A, Guida C

    Primary central mucoepidermoid carcinoma (CMC) of the jaws accounts only for 2-3% of all mucoepidermoid carcinomas reported. Bhaskar in 1963 first analysed the criteria for his central origin, histology and pathogenesis. The authors report a long-term evolution case of CMC of the mandible with peculiar clinical features observed at the Department of Maxillo-Facial Surgery of the School of Medicine and Surgery of the "Federico II" University of Naples (Naples, Italy) examining histopathologic and clinical features and problems related to the treatment.

  • Surgical management of the neck in squamous cell carcinoma of the tongue.

    Publication Date: 01/08/1999 on The British journal of oral & maxillofacial surgery
    by Califano L, Zupi A, Mangone GM, Longo F, Coscia G, Piombino P
    DOI: 10.1054/bjom.1999.0076

    If the nodes are involved, survival of patients with squamous cell carcinoma of the tongue is considerably reduced. Surgery remains the treatment of choice and, to define its role, we have reviewed 82 consecutive cases. Sixty-two cases (76%) were T1-2, and 46 patients (56%) had involved nodes. The cervical region II was the most often involved (n=26). Occult nodal metastases were present in 12 cases. The extent of nodal spread and prognosis varies according to whether the body or the base of the tongue is involved. Lesions of the base with involved node should be treated by a selective posterolateral neck dissection, whilst in the case of a lesion of the body of the tongue, the dissection should be selective anterolateral. In lesions of the base, when there are no nodes involved, a prophylactic selective posterolateral neck dissection is recommended, whilst in the case of the lesions of the body, selective supraomohyoid neck dissection in T2-4 lesions is recommended.

  • [Pathological fracture of the mandible: a report of a clinical case treated with clodronate].

    Publication Date: 01/06/1999 on Il Giornale di chirurgia
    by Califano L, Zupi A, Maremonti P, Longo F, Mangone GM, Marinelli A

    Oral squamous cell carcinoma often invades the mandible. However, the incidence of pathological fractures of the maxillofacial bones is low and their treatment is rarely satisfactory. A patient, too weak to undergo surgery, affected by squamous cell carcinoma of the mandibular region with bone involvement and pathological fracture of the mandible, underwent chemotherapy with carboplatin associated with diphosphonate.

  • Neuroendocrine (Merkel cell) carcinoma of the oral mucosa: report of a case with immunohistochemical study and review of the literature.

    Publication Date: 01/02/1999 on Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
    by Longo F, Califano L, Mangone GM, Errico ME

    Merkel cell carcinoma (Mcc) is an uncommon and aggressive tumour with neuroendocrine features that occur predominantly in the head and neck region. The rarity of this tumour, especially when it arises in the oral mucosa, makes both early identification and standardisation of treatment difficult, particularly as regards complementary treatment. The availability of monoclonal antibodies with restricted specificity for some antigens thought to be related to neuroendocrine carcinomas, such as Merkel cell carcinoma, and ultrastructural studies offer some new leads to investigation. This has allowed, a greater number of these tumours to be discovered, thereby increasing the chances of effective management. A case of Mcc of the floor of the mouth is reported, together with the results of cytokeratin, neuron specific enolase and chromogranin immunohistochemistry.

  • Surgical management of the neck in squamous cell carcinoma of the floor of the mouth.

    Publication Date: 01/11/1998 on Oral oncology
    by Zupi A, Califano L, Mangone GM, Longo F, Piombino P

    Nodal involvement in squamous cell carcinoma considerably lowers survival rate. Despite its importance, neck management has still not been adequately explored. The Authors have retrospectively reviewed the records of 112 cases. Unilateral N+ were treated with a homolateral therapeutic and a controlateral prophylactic neck dissection; bilateral N+ were treated with a bilateral therapeutic neck dissection. On first observation the majority of cases (66.1%) were T1-2, N+ patients accounted for 45.5%. Among N- patients, 21.3% of occult nodal metastases were observed. The 5-year survival rate was 52.7%. With N+ lesions, a radical neck dissection should be performed; the dissection should be performed bilaterally. With N- lesions a prophylactic modified radical neck dissection is recommended in T2-4 lesions.

  • Perineural invasion of the lower alveolar nerve by oral cancer: a follow-up study of 12 cases.

    Publication Date: 01/10/1998 on Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery
    by Zupi A, Mangone GM, Piombino P, Califano L

    Twelve previously untreated cases of oral cancer with perineural infiltration were studied retrospectively. Age, sex, site, clinical stage and outcome were evaluated. Management of the neoplasm in each case involved surgical removal and six patients required adjuvant radiotherapy. The most frequent site was the lip. At the time of diagnosis, five patients had sensory complaints and palpable lymphadenopathy was observed in three patients. The 5-year crude survival rate was 16.7%. In the cases with postoperative assessment of perineural infiltration, a median survival time of 30.8 months was observed; while in the case of preoperative assessment of nerve infiltration, extensive surgery was performed with a consequent median survival time of 44.5 months. The perineural infiltration of the lower alveolar nerve is more common (6.3%) than is generally thought. This frequency is due to the relationship with the lower lip and the mandibular region. In carcinoma of the lip, spread is generally limited to 10-15 mm along the lower alveolar nerve. In carcinoma of the mandibular region, spread is entirely dependent on the location of the tumour; the absence of clinical fixation to the bone and the small size of the carcinoma does not preclude the possibility of bone involvement. Neurological symptoms should be evaluated carefully, and a radiographic investigation of the nerve canal is mandatory.