Dario Grossi

Professor of Neuropsychology

Name Dario
Surname Grossi
Institution Università degli Studi della Campania Luigi Vanvitelli
E-Mail dario.grossi@unicampania.it
Address Villa Camaldoli Foundation Clinic, Naples, Italy; Department of Psychology, University of Campania "Luigi Vanvitelli", Napoli, Italy
Dario Grossi


  • Normative data for the Montreal Cognitive Assessment in an Italian population sample.

    Publication Date: 01/04/2015 on Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
    by Santangelo G, Siciliano M, Pedone R, Vitale C, Falco F, Bisogno R, Siano P, Barone P, Grossi D, Santangelo F, Trojano L
    DOI: 10.1007/s10072-014-1995-y

    The Montreal Cognitive Assessment (MoCA) is a rapid screening battery, also including subtests to assess frontal functions such as set-shifting, abstraction and cognitive flexibility. MoCA seems to be useful to identify non-amnestic mild cognitive impairment (MCI) and subcortical dementia; it has high sensitivity and specificity in distinguishing MCI from mild Alzheimer's Disease. Previous studies revealed that certain items of MoCA may be culturally biased and highlighted the need for population-based norms for the MoCA. The aim of present study was to collect normative values in a sample of Italian healthy subjects. Four hundred and fifteen Italian healthy subjects (252 women and 163 men) of different ages (age range 21-95 years) and educational level (from primary to university) underwent MoCA and Mini Mental State Examination (MMSE). Multiple linear regression analysis revealed that age and education significantly influenced performance on MoCA. No significant effect of gender was found. From the derived linear equation, a correction grid for MoCA raw scores was built. Inferential cut-off score, estimated using a non-parametric technique, is 15.5 and equivalent scores were computed. Correlation analysis showed a significant but weak correlation between MoCA adjusted scores with MMSE adjusted scores (r = 0.43, p < 0.001). The present study provided normative data for the MoCA in an Italian population useful for both clinical and research purposes.

  • The Genesis of Graphic Perseverations in Alzheimer's Disease and Vascular Dementia.

    Publication Date: 01/01/2015 on The Clinical neuropsychologist
    by De Lucia N, Grossi D, Trojano L
    DOI: 10.1080/13854046.2015.1119313

    Perseveration is the involuntary production of iterative responses. This study explored graphic perseverative errors in Alzheimer's disease and vascular dementia, to comprehend the neuropsychological correlates of this behavior.

  • Closing-in in Parkinson's disease individuals with dementia: An experimental study.

    Publication Date: 01/01/2015 on Journal of clinical and experimental neuropsychology
    by De Lucia N, Grossi D, Mauro A, Trojano L
    DOI: 10.1080/13803395.2015.1071339

    The tendency to reproduce figures close to or superimposed on the model in copying tasks, the so-called Closing-in (CI) phenomenon, has been rarely reported in individuals affected by Parkinson's disease and associated dementia (PD-D). We aimed to comprehend the genesis of CI in PD-D individuals by assessing whether reduction of attention/executive resources can increase the tendency to deviate toward the model.

  • Relationships between Environmental Dependency and Closing-in in Patients with Fronto-temporal Dementia.

    Publication Date: 01/01/2015 on Journal of the International Neuropsychological Society : JINS
    by Grossi D, De Lucia N, Milan G, Trojano L
    DOI: 10.1017/S135561771400099X

    Environmental dependency (ED) phenomena, including utilization behavior and imitation behavior, are clinical manifestations typically observed in patients with the behavioral variant of fronto-temporal dementia (bvFTD), who may also show the closing-in (CI) phenomenon. Here, we explored the neuropsychological correlates of ED and CI in bvFTD, and the association of ED with CI to clarify the mechanisms underlying these clinical manifestations. Thirty-one bvFTD patients underwent a wide cognitive assessment in addition to special tasks to detect occurrence of CI and ED phenomena. Both ED and CI phenomena were present in more than half of the sample. Logistic regression analyses revealed that both ED and CI phenomena were significantly associated with poor scores on frontal neuropsychological tests. Although ED and CI often co-occurred, 3/12 patients with CI did not show ED, and 5/18 patients with ED did not show CI. A logistic regression model showed that the presence of ED was not significantly associated to CI. CI and ED are associated to progressive derangement of frontal functions in bvFTD. However, specific frontal dysfunctions might explain the occurrence of either phenomenon in isolation.

  • Closing-in is related to apathy in Alzheimer's disease patients.

    Publication Date: 01/01/2015 on Journal of Alzheimer's disease : JAD
    by Grossi D, de Lucia N, Trojano L
    DOI: 10.3233/JAD-141257

    Apathy and depression are behavioral manifestations that may occur often in Alzheimer's disease (AD) patients. AD patients may also show Closing-in (CI) phenomenon, in graphic copying tasks. Recent evidence would suggest that apathetic symptoms are related to frontal dysfunctions in AD patients, whereas the cognitive bases of depressive symptoms in AD are still unclear. Recent studies demonstrated that frontal dysfunctions are also involved in the genesis of CI in AD patients.

  • Apathy in multiple sclerosis: a validation study of the apathy evaluation scale.

    Publication Date: 15/12/2014 on Journal of the neurological sciences
    by Raimo S, Trojano L, Spitaleri D, Petretta V, Grossi D, Santangelo G
    DOI: 10.1016/j.jns.2014.10.027

    Apathy is defined as lack of motivation affecting cognitive, emotional, and behavioral domains and is usually assessed by standardized scales, such as the Apathy Evaluation Scale (AES). Recently, apathy has been recognized as a frequent behavioral symptom in multiple sclerosis (MS).

  • Apathy in untreated, de novo patients with Parkinson's disease: validation study of Apathy Evaluation Scale.

    Publication Date: 01/12/2014 on Journal of neurology
    by Santangelo G, Barone P, Cuoco S, Raimo S, Pezzella D, Picillo M, Erro R, Moccia M, Pellecchia MT, Amboni M, Santangelo F, Grossi D, Trojano L, Vitale C
    DOI: 10.1007/s00415-014-7498-1

    Apathy is a behavioural disturbance occurring alone or in concomitance with depression in Parkinson's disease (PD). Here we present a validation study for the self-report version of the Apathy Evaluation Scale (AES-S), carried out in a sample of 60 non-demented, non-depressed untreated, drug-naïve, de novo PD patients; 20 patients of the sample (33.3%) were classified as apathetic according to current clinical criteria. All enrolled patients completed the AES-S and a neurological and cognitive assessment. Mean AES-S score was 34.43. AES-S did not show floor or ceiling effect. Cronbach's alpha was 0.872. Principal component analysis revealed three factors: the first (34.4% of the variance) represented constitutive aspects of the construct of apathy; the second (8.5% of the variance) represented a social dimension; the third factor (7.9% of the variance) represented a dimension related to insight. With respect to clinical criteria for apathy considered as the gold standard, receiver operating characteristics curve analysis showed that a cut-off of 36/37 has the maximum discrimination power. High sensitivity and negative predictive values were obtained with cut-off scores of 33/34 or lower; high specificity and positive predictive values were obtained with cut-off scores of 38/39 or higher. AES-S score correlated with scores on frontal tasks, but not on Beck Depression Inventory, Unified Parkinson's Disease Rating Scale, Hoehn and Yahr scale. The AES-S is a reliable and valid questionnaire for detecting apathy in PD. For screening purposes a 33/34 cut-off score is indicated, but a 38/39 cut-off score is necessary when a high specificity is desired.

  • The brain network for self-feeling: a symptom-lesion mapping study.

    Publication Date: 01/10/2014 on Neuropsychologia
    by Grossi D, Di Vita A, Palermo L, Sabatini U, Trojano L, Guariglia C
    DOI: 10.1016/j.neuropsychologia.2014.08.004

    Ongoing signals from one's own body (interoception) allow experience of self-feeling. In early studies interoception strictly referred to the awareness of visceral sensation but recent theories have expanded this concept to denote the ongoing status of the body. Here we asked left and right focal brain-damaged patients to answer questions about their interoceptive feelings, and correlated their responses to a quantitative measure of their lesions (voxel-based symptom-lesion mapping). By these means we could reveal that three key structures contribute to building up the feeling of self, namely insula (interoceptive modulator), amygdala (emotional modulator) and putamen (motor modulator). This brain network may be necessary for the integrity of self-feeling. A dysfunction of this network might impair perception of the inner body state, and also account for psychological disturbances, such as the somatic symptom disorders, in which individuals experience subjective symptoms suggesting physical illness or injury despite medical test results which are normal, and clinical examination do not disclose relevant medical conditions.

  • Structural connectivity in a single case of progressive prosopagnosia: the role of the right inferior longitudinal fasciculus.

    Publication Date: 01/07/2014 on Cortex; a journal devoted to the study of the nervous system and behavior
    by Grossi D, Soricelli A, Ponari M, Salvatore E, Quarantelli M, Prinster A, Trojano L
    DOI: 10.1016/j.cortex.2012.09.010

    Progressive prosopagnosia (PP) is a clinical syndrome characterized by a progressive and selective inability to recognize and identify faces of familiar people. Here we report a patient (G.S.) with PP, mainly related to a prominent deficit in recognition of familiar faces, without a semantic (cross-modal) impairment. An in-depth evaluation showed that his deficit extended to other classes of objects, both living and non-living. A follow-up neuropsychological assessment did not reveal substantial changes after about 1 year. Structural MRI showed predominant right temporal lobe atrophy. Diffusion tensor imaging was performed to elucidate structural connectivity of the inferior longitudinal fasciculus (ILF) and the inferior fronto-occipital fasciculus (IFOF), the two major tracts that project through the core fusiform region to the anterior temporal and frontal cortices, respectively. Right ILF was markedly reduced in G.S., while left ILF and IFOFs were apparently preserved. These data are in favour of a crucial role of the neural circuit subserved by right ILF in the pathogenesis of PP.

  • Affective theory of mind in patients with Parkinson's disease: comment.

    Publication Date: 01/03/2014 on Psychiatry and clinical neurosciences
    by Santangelo G, Vitale C, Errico D, Grossi D, Trojano L, Barone P